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Photodynamic and Sonodynamic Therapies Photodynamic therapy (PDT) and sonodynamic therapy (SDT) are emerging modalities for non-invasive cancer treatment, based on the tumor-selective accumulation of non-toxic molecules [photosensitizers (PS) or sonosensitizers (SS)], which are activated by laser light or ultrasound radiation to produce a localized cytotoxic effect via ROS generation [1024,1025,1026,1027]

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Indeed, the apical localisation of SOP enzymes in human colonic crypts places this pathway optimally at the host–microbiome interface